De legendarische half-vampier, half-menselijke vampierjager Blade volgt Deacon Frost, een zeer machtige en invloedrijke vampier die zijn moeder heeft vermoord en die leiding geeft aan Existence, een geheimzinnige vampierorganisatie die actief is in Zuidoost-Azië.
| Production | Taro Morishima | Producer |
| Sound | Tetsuya Takahashi | Music |
| Sound | Shogo Ohnishi | Music |
| Production | Fuminori Hara | Producer |
| Camera | 川下裕樹 | Director of Photography |
| Sound | Reiji Kitasato | Music |
| Production | Cort Lane | Producer |
| Writing | Marv Wolfman | Characters |
| Writing | Gene Colan | Characters |
| Sound | 中嶋聡彦 | Sound Director |
| Visual Effects | Cindy H. Yamauchi | Character Designer |
| Production | 滝山正夫 | Executive Producer |
| Production | Alan Fine | Executive Producer |
| Production | Eric S. Rollman | Executive Producer |
| Production | Simon Philips | Executive Producer |
| Production | Jeph Loeb | Executive Producer |
| Production | Dan Buckley | Executive Producer |
| Production | Joe Quesada | Co-Executive Producer |
| Production | Megan Thomas Bradner | Associate Producer |
| Writing | Warren Ellis | Story |
| Production | Stan Lee | Co-Executive Producer |
