De legendarische half-vampier, half-menselijke vampierjager Blade volgt Deacon Frost, een zeer machtige en invloedrijke vampier die zijn moeder heeft vermoord en die leiding geeft aan Existence, een geheimzinnige vampierorganisatie die actief is in Zuidoost-Azië.
| Camera | 川下裕樹 | Director of Photography |
| Production | Cort Lane | Producer |
| Production | Fuminori Hara | Producer |
| Production | Taro Morishima | Producer |
| Sound | Reiji Kitasato | Music |
| Sound | Shogo Ohnishi | Music |
| Sound | 高橋徹也 | Music |
| Writing | Marv Wolfman | Characters |
| Writing | Gene Colan | Characters |
| Sound | 中嶋聡彦 | Sound Director |
| Visual Effects | Cindy H. Yamauchi | Character Designer |
| Writing | Warren Ellis | Story |
| Production | Jeph Loeb | Executive Producer |
| Production | Alan Fine | Executive Producer |
| Production | Dan Buckley | Executive Producer |
| Production | Eric S. Rollman | Executive Producer |
| Production | Simon Philips | Executive Producer |
| Production | Joe Quesada | Co-Executive Producer |
| Production | Stan Lee | Co-Executive Producer |
| Production | 滝山正夫 | Executive Producer |
| Production | Megan Thomas Bradner | Associate Producer |
